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R countries, with significant delays in reporting. Diagnostic laboratories will need

10.00 $
Published date: 2024/04/17
  • Location: V0x 1l0, Hope, BC, United States
R countries, with significant delays in reporting. Diagnostic laboratories will need validated, commercial apixaban controls and calibrators to adapt their anti-Xa assays for apixaban. Although commercial research-use only apixaban-specific calibrators are currently available in Australia, a standard curve constructed with commercial LMWH standards was reported to show an equally strong correlation with apixaban plasma concentration (r2 = 0.89) as one constructed with apixaban (r2 = 0.88) [11]. A dilute prothrombin time (dPT), achieved by diluting the thromboplastin reagent in 100 mmol/L CaCl2, has been proposed as an improved assay for factor Xa inhibitors [12]. This modification prolonged the PT measurements at therapeutic concentrations of apixaban and showed greater sensitivity than a standard PT [12]. However, others have found that dPT was no better than PT in terms of sensitivity [9], suggesting that further development of these assays is needed.

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